type 2 diabetes mellitus and risk of malignant melanoma: a systematic review and meta-analysis of cohort studies.
نویسندگان
چکیده
epidemiology studies have demonstrated inconsistent associations between type 2 diabetes mellitus and the risk of malignant melanoma. to this end, the aim was to perform a meta-analysis of cohort studies.medline, pubmed, embase and the cochrane library were searched up to february 2014. cohort studies addressing the relative risk of type 2 diabetes mellitus on malignant melanoma were included in this meta-analysis. the newcastle-ottawa scale was applied for quality evaluation. the pooled relative risks with the corresponding 95% confidence intervals (95% cis) were calculated by using random-effects or random-effects model. heterogeneity and publication bias were evaluated by i (2) and funnel plot analysis, respectively. data was analyzed using stata 11.0.a total of 9 independent cohorts from 8 manuscripts were entered this meta-analysis. type 2 diabetes mellitus was slightly associated with an increased risk of malignant melanoma, and the pooled relative risk was 1.15 (95% ci, 1.00-1.32) in diabetes compared with non-diabetes with significant evidence of heterogeneity among these studies (p=0.016, i (2) =57.6%). for the studies adjusted for age, gender and obesity, the relative risks were 1.21 (95% ci, 1.03-1.42), 1.17 (95% ci, 1.01-1.35) and 1.11 (95% ci, 1.00-1.24), respectively. for the population-based studies in which case cohort established, the relative risk was 1.85 (95% ci, 1.31-2.62).type 2 diabetes might be an independent risk factor for malignant melanoma. further studies are needed to specifically test the effect, and fully elucidate the underlying pathophysiologic mechanisms.
منابع مشابه
Type 2 Diabetes Mellitus and Risk of Malignant Melanoma: A Systematic Review and Meta-Analysis of Cohort Studies
BACKGROUND Epidemiology studies have demonstrated inconsistent associations between type 2 diabetes mellitus and the risk of malignant melanoma. To this end, the aim was to perform a meta-analysis of cohort studies. METHOD Medline, PubMed, Embase and the Cochrane Library were searched up to February 2014. Cohort studies addressing the relative risk of type 2 diabetes mellitus on malignant mel...
متن کاملEfficacy of insulin targeted gene therapy for type 1 diabetes mellitus: A systematic review and meta-analysis of rodent studies
Objective(s): Diabetes mellitus (DM) is a major worldwide public health challenge, for which gene therapy offers a potential therapeutic approach. To date, no systematic review or meta-analysis has been published in this area, so we examined all relevant published studies on rodents to elucidate the overall effects of gene therapy on bodyweight, intraperitoneal glucose...
متن کاملAssociation of MiR-146a Expression and Type 2 Diabetes Mellitus: A Meta-Analysis
Although deregulation of miR-146a has been reported in type 2 diabetes repeatedly, the direction of deregulation events (up or down) remained to be inconsistent in literatures. Therefore, in this study, we performed a meta-analysis on the possible association between miR-146a expression levels and type 2 diabetes. A systematic literature searching of PubMed, ISI Web of Science and Google ...
متن کاملTea consumption and risk of type 2 diabetes mellitus: a systematic review and meta-analysis update
OBJECTIVE Tea has been suggested to decrease blood glucose levels and protect pancreatic β cells in diabetic mice. However, human epidemiological studies showed inconsistent results for the association between tea consumption and type 2 diabetes mellitus (T2DM) risk. The aim of this study was to conduct a meta-analysis to further explore the association between tea consumption and incidence of ...
متن کاملEffect of Empagliflozin on Electrolytes and Lipid Profiles in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis
Introduction: Studies examining the effect of Empagliflozin in patients with type 2 diabetes have reported different results regarding the effect of this drug on electrolytes and lipid profiles. This study aimed to evaluate the effect of Empagliflozin on electrolytes and lipid profiles in patients with type 2 diabetes. Materials and Methods: In this systematic meta-analysis, clinical trials pub...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of public healthجلد ۴۳، شماره ۷، صفحات ۸۵۷-۶۶
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023